In 2007，Sheng Zhiguo worked at Zhengzhou Tobacco Research Institute of CNTC as a assistant professor, following obtaining doctorate in Hygiene Toxicology from Academy of Military Medical Sciences; From 2008 until the present, I have been employed at State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, CAS. I had studied and researched in the Harvard Medical School from Mar 2015 to Apr 2016 as a visiting scholar. In recent years, I have seven important papers as the first author published in the international famous toxicology journals, such as Environ. Health Perspect.，J. Pharmacol. Exp. Ther., and Toxicol. Appl. Pharmacol, and participated in compilation of toxicology book.  

　　The effects of co-exposure among environmental factors on human health and involved mechanism(s)  

　　[1] Sheng, Z.G., Huang, W., Liu, Y.X., Zhu, B.Z. (2013) Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression. Toxicol. Appl. Pharmacol. 267: 88-94.

　　[2] Sheng, Z.G., Huang, W., Liu, Y.X., Yuan, Y., Zhu, B.Z. (2013) Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. Toxicol. Appl. Pharmacol. 267: 74-87.

　　[3] Sheng, Z.G., Li, Y., Fan, R.M., Chao, X.J., Zhu, B.Z. (2013) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex. Toxicol. Appl. Pharmacol. 266: 335-344.

　　[4] Sheng, Z.G., Tang, Y., Liu, Y.X., Yuan, Y., Zhao, B.Q., Chao, X.J., Zhu, B.Z. (2012) Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism. Toxicol. Appl. Pharmacol. 259: 133-142.

　　[5] Sheng, Z.G., Zhu, B.Z. (2011) Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α. Environ. Health Perspect. 119: 1175-1780.

　　[6] Sheng, Z.G., Cao, X., Peng, S., Wang, C., Li, Q., Wang, Y., Liu, M. (2008) Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway. Toxicol. Appl. Pharmacol. 226: 119-127.

　　[7] Sheng, Z.G., Peng, S., Wang, C.Y., Li, H.B., Hajela, R.K., Wang, Y.E., Li, Q.Q., Liu, M.F., Dong, Y.S., Han, G. (2007) Apoptosis in microencapsulated juvenile rabbit chondrocytes induced by ofloxacin: role played by beta(1)-integrin receptor. J. Pharmacol. Exp. Ther. 322: 155-165.

　　[8] Fan RM, Zhu BZ, Huang CP, Sheng ZG, Mao L, Li MX. (2015) Different modes of synergistic toxicities between metam/copper (II) and metam/zinc (II) in HepG2 cells: apoptosis vs. necrosis.Environ Toxicol.doi: 10.1002/tox.22197. [Epub ahead of print].

　　[9] Duan H, He Z, Ma J, Zhang B, Sheng ZG, Bin P, Cheng J, Niu Y, Dong H, Lin H, Dai Y, Zhu B, Chen W, Xiao Y, Zheng Y. (2013) Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon.Arch Toxicol. 87(11):2013-2022.

　　[10] Wang Y, Lu C, Sheng ZG, Liu G, Fu Z, Zhu B, Peng S. (2011) Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats.J Environ Sci (China). 23(1):119-124.

　　[11] Lu C, Wang Y, Sheng ZG, Liu G, Fu Z, Zhao J, Zhao J, Yan X, Zhu B, Peng S.(2010) NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats.Toxicol ApplPharmacol. 248(3):178-184.

　　[12] Li Q, Peng S, Sheng ZG, Wang Y. (2010) Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits: excessive production of reactive oxygen species, lipid peroxidation and DNA damage.Eur J Pharmacol. 2010 Jan 25;626(2-3):146-153.

　　National Natural Science Foundation of China (Grant NO:21377158 and 20907070 as Project director; 21237005 and 20890112 as Major member) 

　　Outstanding doctoral thesis from Academy of Military Medical Sciences