I graduated from State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University with a Ph.D degree in 2005 and then continued my post-doc research at College of Chemistry and Molecular Engineering, Peking University in 2006. I joined the Research Center for Eco-environmental Sciences, CAS, in 2008.

Biosensor and environmental toxicology

[1] Yuxin Gu, Yu Yang*, Bin Wan, Minjie Li, Liang-Hong Guo*. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells–A molecular mechanism of organophosphate flame retardants developmental neurotoxicity. Biochem. Pharmacol., 2018, 152: 21-33. [2] Yu Yang*, Yuxin Gu, Bin Wan, Xiaomin Ren, Liang-Hong Guo*. Label-free electrochemical biosensing of small-molecule inhibition on O-GlcNAc glycosylation. Biosens. Bioelectron., 2017, 95(1): 94-99.
[3] Yu Yang, Qi-Yan Lv, Liang-Hong Guo*, Bin Wan, Xiao-Min Ren, Ya-Li Shi, Ya-Qi Cai. Identification of protein tyrosine phosphatase SHP-2 as a new target of perfluoroalkyl acids in HepG2 Cells. Arch. Toxicol., 2017, 91(4): 1697-1707.
[4] Sufang Wang, Qiyan Lv, Yu Yang*, Liang-Hong Guo*, Bin Wan, Xiaomin Ren, Hui Zhang. Arginine decarboxylase: a novel biological target of mercury compounds identified in PC12 cells. Biochem. Pharmacol., 2016, 118, 109-120.
[5] Sufang Wang, Bin Wan, Lianying Zhang, Yu Yang*, Liang-Hong Guo*. In vitro inhibition of lysine decarboxylase activity by organophosphate esters. Biochem. Pharmacol., 2014, 92(3): 506-516.
[6] Sufang Wang, Qiyan Lv, Yu Yang*, Liang-Hong Guo*, Bin Wan, Lixia Zhao. Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase. Sci. Total Environ., 2014, 496: 381-388.
[7] Yu Yang, Liang-Hong Guo*, Na Qu, Ming-Yuan Wei, Li-Xia Zhao, Bin Wan. Label-free electrochemical measurement of protein tyrosine kinase activity and inhibition based on electro-catalyzed tyrosine signaling. Biosens. Bioelectron., 2011, 28, 284-290.
[8] Yu Yang, Lixia Zhao*. Sensitive fluorescent sensing for DNA assay. TRAC-Trend Anal.Chem., 2010, 29, 980-1003.
[9] Yu Yang, Jianhui Jiang, Guoli Shen, Ruqin Yu*. An optical sensor for mercury ion based on the fluorescence quenching of tetra(p-dimethylaminophenyl)porphyrin. Anal. Chim. Acta, 2009, 636, 83-88.

Supported Projects:
[1] NSFC project: Study on perfluorinated compounds recognition for new target-protein tyrosine phosphatase and molecular mechanism of toxicity. 21577163, Project leader, 2016.01-2019.12.
[2] NSFC project: Study for rapid screening of persistent toxic substance’s disrupting effect on the reversible protein glycosylation and related mechanism. 21377142, Project leader, 2014.01-2017.12.
[3] NSFC project: Study on the toxic interaction between dioxins and amino acid decarboxylase based on supramolecular fluorescence switch system. 21077124, Project leader, 2011.01-2013.12.
[4] NSFC project: Study on the interaction and genotoxicity of polycyclic aromatic hydrocarbons (PAHs) metabolites with p53 Gene by resonance light scattering. 20907068, Project leader, 2010.01-2012.12.
[5] China Postdoctoral Foundation: Study on the novel supramolecular chemical sensor based on the combination of electrospinning and molecular imprinting technology. 20070410017, Project leader, 2007.10-2008.09.