Faculty and Staff
YAO Xinglei
Title:
Highest Education: Ph.D
Office: 18 Shuangqing Road, Haidian District, Beijing, China
Phone: 010-62849096
Zip Code: 100085
Fax: 010-62849096
Email: xlyao@rcees.ac.cn
Education and Appointments:

2000.9-2004.7 Double Bachelor, Biology & Computer, Lanzhou University, China.
2005.4-2007.3 Master, Pharmaceutics, Osaka University, Japan.
2007.4-2010.3 Ph.D., Pharmaceutics, Osaka University, Japan.
2010.5-2012.7 Postdoctoral Fellow, Pharmaceutics, Zhejiang University, China.
2012.9-2014.7 Postdoctoral Fellow, Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, China.
2014.7-Present RCEES, CAS, China.

Research Interest:

Environmental Toxicology

Selected Publications:
  1. Yao XL, Cao D, Wang FB, Zhang WJ, Ma CY, Song MY. An overview of omics approaches to characterize the effect of perfluoroalkyl substances in environmental health. Trac-Trend Anal Chem (2019) 121115367
  2. Li X, Li A, Zhang W, Liu X, Liang Y, Yao X*, Song M. A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals. Ecotoxicol Environ Saf (2019) 186: 109755
  3. Li H1, Zhu L1, Chen H1, Li T1, Han Q1, Wang S1, Yao X1, Feng H, Fan L, Gao S, Boyd R, Cao X, Zhu P, Li J, Keating A, Su X, Zhao RC. Generation of Functional Hepatocytes from Human Adipose-Derived MYC+ KLF4+ GMNN+ Stem Cells Analyzed by Single-Cell RNA-Seq Profiling. Stem cells translational medicine(2018) 7: 792-805
  4. Yao XL, Yin NY, Faiola F. Stem cell toxicology: a powerful tool to assess pollution effects on human health. Natl Sci Rev (2016) 3: 430-450
  5. Wan L1, Yao X1, Faiola F, Liu B, Zhang T, Tabata Y, Mizuguchi H, Nakagawa S, Gao JQ, Zhao RC. Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells. Int J Nanomedicine (2016) 11: 6763-6769
  6. Yao X1, Zhou N1, Wan L, Su X, Sun Z, Mizuguchi H, Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ. Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells. Biochem Biophys Res Commun (2014) 447: 383-387
  7. Yao XL, Yoshioka Y, Ruan GX, Chen YZ, Mizuguchi H, Mukai Y, Okada N, Gao JQ, Nakagawa S. Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy. Biomacromolecules (2012) 13: 2402-2409
  8. Yao XL, Nakagawa S, Gao JQ. Current targeting strategies for adenovirus vectors in cancer gene therapy. Curr Cancer Drug Targets (2011) 11: 810-825
  9. Yao X1, Yoshioka Y1, Morishige T, Eto Y, Narimatsu S, Kawai Y, Mizuguchi H, Gao JQ, Mukai Y, Okada N, Nakagawa S. Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy. Mol Ther (2011) 19: 1619-1625
  10. Yao X1, Yoshioka Y1, Morishige T, Eto Y, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Nakagawa S. Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration. Biol Pharm Bull (2010) 33: 1073-1076 
  11. Yao X1, Yoshioka Y1, Morishige T, Eto Y, Watanabe H, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S. Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis. Gene Ther (2009) 16: 1395-1404
  12. Yao X1, Yoshioka Y1, Eto Y, Morishige T, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S. TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection. Biochem Biophys Res Commun (2007) 362: 419-424
Supported Projects:

National Natural Science Foundation of China, General Project, 2016.01-2019.12, in charge.
National Natural Science Foundation of China, Young Scientist Project, 2012.01-2014.12, in charge.
Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, 2013.01-2014.12, in charge.
China Postdoctoral Science Foundation, 2010.09-2012.06, in charge.

Honors:

Chinese Government Award for Outstanding Self-Financed Students Abroad,2009

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