Faculty and Staff----Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences

Education and Appointments：

Guohua Wei, Ph.D. associate professor, major research was focused on the structural modification, chemical synthesis and bioactivity study of potent natural oligosaccharides and their derivatives (including avermectin, 3-sophorotrioside, solamargine and solamarine); finding some new glycosylation conditions for the oligosaccharides synthesis; solid-phase synthesis of the branched oligosaccharides using a highly efficient synthetic strategy. Twenty papers (J. Org. Chem., Org. Lett., Tetrahedron Lett., Tetrahedron, and Carbohydr. Res.) have been published on famous international journal, and two Chinese Patents have been applied since 2002.

Research Interest：

Structural modification, chemical synthesis and bioactivity study of potent natural oligosaccharides and their derivatives; finding some new glycosylation conditions for the oligosaccharides synthesis; solid-phase synthesis of the branched oligosaccharides using a highly efficient synthetic strategy.

Selected Publications：

1. Guohua Wei, Vipin Kumar, Jun Xue, Robert D. Locke, Khushi L. Matta
The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs), Tetrahedron Letters, 2009, 50, 5920-5922
2. Guohua Wei, Xun Lv, Yuguo Du,
FeCl3-catalyzed α-glycosidation of glycosamine pentaacetates, Carbohydr. Res., 2008, 343, 3096-3099
3. Guohua Wei, Lei Zhang, Chao Cai, Yuguo Du,
Selective cleavage of sugar anomeric O-acyl groups using FeCl3·6H2O, Tetrahedron Letters, 2008, 49, 5488-5491
4. Yuguo Du*, Guohua Wei, Shuihong Cheng, HClO4-SiO2 catalyzed glycosylation using sugar trichloroacetimidates as glycosyl donors Tetrahedron Letters, 2006, 47, 307-310
5. Total synthesis of Quercetin 3-Sophorotrioside.
Yuguo Du*, Guohua Wei, R.J. Linhardt*, J. Org. Chem., 2004, 69, 2206-2209.
6. New Potent Insecticidal Agent: 4'-Fucosyl Avermectin Derivative.
Guohua Wei, Yuguo Du*, R.J. Linhardt*, Tetrahedron Lett., 2004, 45, 6895-6898.
7. The first total synthesis of calabricoside A.
Yuguo Du*, Guohua Wei, R.J. Linhardt*, Tetrahedron Lett., 2003, 44, 6887-6890.
8. Silver triflate, a mild alternative catalyst for glycosylation conditions using trichloroacetimidates as glycosyl donors.
Guohua Wei, Guofeng Gu, Yuguo Du*, J. Carbohydr. Chem., 2003, 22, 385-393.

Supported Projects：

Structural modification, chemical synthesis and bioactivity study of potent natural oligosaccharides and their derivatives; finding some new glycosylation conditions for the oligosaccharides synthesis; solid-phase synthesis of the branched oligosaccharides using a highly efficient synthetic strategy.

Honors：

Presidential Award of Chinese Academy of Sciences